Electromechanical resonators such as quartz crystals, surface acoustic wave (SAW) resonators, and ceramic resonators have become essential components in electronic…
Modeling etch-rate variation in Deep Reactive Ion Etching (DRIE) helps to identify possible defects in MEMS and IC devices arising…
This work presents the size-selective sorting of single biological cells using Templated Assembly by Selective Removal (TASR). We have demonstrated…
Standard photolithography-based methods for fabricating micro-electromechanical systems (MEMS) present several drawbacks including incompatibility with flexible substrates and limitations to wafer-sized…
Stem cell phenotype and function are influenced by microenvironmental cues comprised of the cell-cell, cell-extracellular matrix (ECM), cell-media interactions, and…
Change in cell stiffness is a characteristic of several blood cell diseases, such as sickle cell anemia, malaria, and leukemia….
Enzyme-Linked Immunosobent Assay (ELISA) is the gold standard in biodetection due to its high reproducibility and sensitivity. Still, the ultimate…
Mass spectrometers are powerful analytical instruments that are known to be the gold standard for chemical analysis. The Micro-Gas Analyzer…
The Micro-Gas Analyzer Project attempts to leverage the cost reduction, performance enhancement, and increased portability associated with MEMS to create…
The manipulation of liquid spreading is important for a broad range of microfluidic, biological, and thermal management applications. In this…
Microscale ejector pumps offer the potential for high-flow-rate pumping of gases, a functionality that is greatly needed in MEMS technology….
Silicon CMOS circuits have a well-defined lower limit on their achievable energy efficiency due to subthreshold leakage. Once this limit…
During reentry, the formation of a high-density, low-temperature plasma sheath around a spacecraft results in a communications blackout. Advanced plasma…
Mammalian cell culture dominates the biopharmaceutical industry for biotherapeutics including monoclonal antibodies, vaccines, and growth factors. However, mammalian cells are…
Singlet delta oxygen (O2(a)) may be synthesized through the highly exothermic multiphase reaction of gaseous Cl2 with an aqueous mixture…
Chalcogenide glasses are widely used as “phase change materials” for optical data storage media in rewritable compact discs (CD±RW) and…
A novel ultra-wide-band resonating thin-film PZT MEMS energy-harvester has been developed. It harvests energy from parasitic ambient vibration at a…
Developing highly productive cell-culture processes is an essential step in the production of biopharmaceutical products. Process development involves experimentally determining…
To ensure safe operation during space missions, NASA is sponsoring research on advanced sensing systems. In this endeavor, one particular…
Cell fusion has been used for many purposes, including generating hybridomas and reprogramming somatic cells. The fusion step is the…
This project looks to develop the technology for field-enabled low-power portable vacuum sources that can be made cheaply and reliably,…
Microfluidics offer a unique platform for screening the effects of the biochemical and biophysical microenvironment on cellular phenotype, while allowing…
Loop heat pipes (LHPs) are a widely-used component in the thermal management of high-power electronics. LHPs transfer heat by utilizing…
The shortage of fresh water is a serious global problem, and an energy-efficient desalination strategy can provide a substantial solution…
This research involves the development of architectures for screening complex phenotypes in biological cells. We augment microscopy with the ability…
For systems biology, the models are more often limited by the absence of reliable experimental data than by available computational…
Understanding how the rate of cell growth changes during the cell cycle and in response to growth factors and other…
Micro- and nanomechanical cantilevers are widely used as sensitive probes for physical measurements in materials science, engineering, and biology. In…
Traditionally, RF circuits for wireless communications have used large-sized and low-quality-factor (Q) electrical RF components such as oscillators and filter…
The development of portable power-generation systems remains an important goal, with applications ranging from the automobile industry to the portable…
The recent development of “low power” (10s-100s of μW) sensing and data transmission devices, as well as protocols with which…
Autocrine signaling plays a key role in tumorigenesis and in the maintenance of various physiologic states. Our research involves the…
The development of new techniques to separate and characterize cells with high throughput has been essential to many of the…
Catalyst immobilization on heterogeneous supports affords several advantages over homogeneous catalysts for chemical synthesis in continuous flow processes. The use…
Multi-axis force-sensing at the micro-scale is necessary for a wide range of applications in biology, materials science, and nanomanufacturing. A…
Prediction and optimization of liquid propagation rates in micropillar arrays are important for various lab-on-chip, biomedical, and thermal management applications….
Diffraction gratings and other periodic patterns have long been important tools in research and manufacturing. Diffraction occurs due to the…
Isoelectric point (pI)-based fractionation is ideally suited for the first-dimensional separation because the pI value of any peptide or protein…
Embryonic development is a complex dynamic process, whereby spatial organization of molecular signals instructs stem cells to adopt various differentiation…
Significant interest exists in creating insect-based Micro-Air-Vehicles (MAVs) that would combine advantageous features of insects—small size, effective energy storage, navigation…
The mechanical properties of thin films, especially residual stresses in as-deposited films, strongly influence the reliability and performance of microelectromechanical…
Ionic Liquid Ion Sources (ILIS) are a subset of electrospray emitters characterized by pure ion emission from room-temperature ionic liquids….
Research efforts on MEMS-based analytical instrumentation have focused on the development of rugged gas chromatography and mass spectrometry (GC/MS) systems…
A novel sensing technology for unmanned undersea vehicles (UUVs) is under development. The project is inspired by the lateral line…
Cytokinesis is the final stage of cell division when eukaryotes assemble a contractile acto-myosin ring to physically divide their cytoplasm…