MTL Annual Report

Collaborators

• C. Chen, UPenn
• B. Engelward, MIT Biological Eng.
• T. Golub, Broad Institute
• C. Marcus, Harvard
• L. Mahadevan, Harvard University
• D. Melton, Harvard University
• E. Ruoslahti, Burnham Institute
• M. Sailor, UCSD
• R. Sasisekharan, MIT
• P. Sharp, MIT
• J. Shah, Harvard
• S. Suresh, MIT
• K. Van Vliet, MIT
• R. Weissleder, HMS

POSTDOCTORAL associates

• N. Singh
• D. Wood
• S. March
• K. Stevens
• R. Schwartz
• G. Kwong

Graduate Students

• A. Chen, Res. Asst., HST
• J. Shan, Res. Asst., HST
• Y. Ren, MD/PhD, HST
• N. Reticker-Flynn, Res. Asst., HST
• K. Trehan, Res. Asst., HST
• K. Lin, Res. Asst., ChemE
• C. Li, Res. Asst., ChemE
• S. Ng, Res. Asst., BioE

Support Staff

• S. Kangiser, Admin. Asst. II
• S. Katz, Laboratory Manager
• E. Lehtola, Technical Assistant
• G. Underhill, Senior Research Scientist

Publications

Albrecht, DR, Underhill, GH, Resnikoff, J, Mendelson, A, Bhatia, SN, and Shah, JV (2010 in press): Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics. Integrative Biology.

Jones, CT, Catanese, MT, Law, LMJ, Khetani, SR, Syder, AJ, Ploss, A, Oh, TS, Schoggins, JW, MacDonald, MR, Bhatia, SN, and Rice, CM (2010): Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system. Nature Biotechnology. 28, 167-171

Ploss, A, Khetani, SR, Jones, CT, Sydera, AJ, Trehan, K, Gaysinskaya, VA, Mua, K, Ritola, K, Rice, CM, and Bhatia, SN (2010): Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures. PNAS, published online before print February 1

Harris, TJ, Green, JJ, Fung, PW, Langer, R, Anderson, DG, and Bhatia, SN (2010): Tissue-specific gene delivery via nanoparticle coating. Biomaterials, 31: 998-1006

Park,J-H, von Maltzahn, G, Xu, MJ, Fogal, V, Kotamraju,VR, Ruoslahti, E, Bhatia, SN, & Sailor, MJ (2010): Cooperative nanomaterial system to sensitize, target, and treat tumors. PNAS, 107: 981-986

Agrawal, A, Min, D-H, Singh, N, Zhu, H, Birjiniuk, A,von Maltzahn, G, Harris, T, Xing, D, Woolfenden, S, Sharp, P, Charest, A, and Bhatia, SN (2009): Functional delivery of siRNA in mice using dendriworms. ACS Nano. 3: 2495–2504.

March, S, Hui, EE, Underhill, GH, Khetani, S, and Bhatia, SN (2009). Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro. Hepatology, 50: 920-928.

von Maltzahn, G, Centrone, A.,Park,J-H, Ramanathan, R, Sailor, MJ, Hatton, TA, and Bhatia, SN (2009): SERS-Coded gold nanorods as a multifunctional platform for densely multiplexed near-infrared imaging and photothermal heating. Advanced Materials, 21: 3175-3180

von Maltzahn, G., Park, J-H, Agrawal, A, Bandaru, NK, Das, SK, Sailor, MJ, and Bhatia, SN (2009 in press):  Computationally-guided photothermal tumor therapy using long-circulating gold nanorod antennas. Cancer Research

Higgins , J, Eddington, D , Bhatia, SN, Mahadevan, L (2009): Statistical dynamics of flowing red blood cells by morphological image processing. PLoS Computational Biology. 5 (2), e1000288.

Chen, AA[†], Khetani, SR[†], Lee, S, Bhatia, SN, Van Vliet, KJ (2009, in press): Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers. Biomaterials 30: 1113-1120. [†] These authors contributed equally

J.H. Park, G. von Maltzahn, M.P. Schwartz, E. Ruoslahti, S.N. Bhatia, M.J. Sailor, “Magnetic iron oxide nanoworms for tumor targeting and imaging,” Advanced Materials, vol. 20, no. 9, pp. 1630-1635, May 2008.

Flaim CJ, Teng D, Chien S, and Bhatia, SN (2008). Combinatorial signaling microenvironments for studying stem cell fate. Stem Cells and Development, 17: 1–11.

S.R. Khetani and S.N. Bhatia, “Microscale human liver tissue for drug development,” Nature Biotechnology, vol. 26, no. 1, pp. 120-126, Jan. 2008.

Albrecht, DR, Underhill, GH, Mendelson, A, Bhatia, SN (2007). Multiphase electropatterning of cells and biomaterials. Lab on a Chip, 7: 702 – 709.

A.M. Derfus, A.A. Chen, D.H. Min, E. Ruoslahti, and S.N. Bhatia, “Targeted quantum dot conjugates for siRNA delivery,” Bioconjugate Chemistry, vol. 18, no. 5, pp. 1391-1396, Sept. 2007.

J.M. Higgins, D.T. Eddington, S.N. Bhatia, and L. Mahadevan, “Sickle-cell vasoocclusion and rescue in a microfluidic device,” Proc. National Academy of Sciences, vol. 104, no. 51, pp. 20496-20500, Dec. 2007.

A.M. Derfus, G. von Maltzahn, T.J. Harris, T. Duza, K.S. Vecchio, E. Ruoslahti, and S.N. Bhatia, “Remotely triggered release from magnetic nanoparticles,” Advanced Materials, vol. 19, pp. 3932-3936, 2007.

G. von Maltzahn, T.J. Harris, J.H. Park, A.J. Schmidt, M.J. Sailor, and S.N. Bhatia, “Nanoparticle self-assembly gated by logical proteolytic triggers,” Journal of the American Chemical Society, vol. 129, pp. 6064-6065, 2007.

E.E. Hui and S.N. Bhatia, “Micromechanical control of cell-cell interactions,” Proc. National Academy of Sciences, vol. 104, pp. 5722-5726, 2007.

V. Liu Tsang, A.A. Chen, L.M. Cho, K.D. Jadin, R.L. Sah, S. DeLong, J.L. West, and S.N. Bhatia, “Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels,” FASEB Journal, vol. 21, pp. 790-801, 2007.

S.R. Khetani and S.N. Bhatia, “Engineering tissues for in vitro applications,” Current Opinion in Biotechnology, vol. 17, pp. 524-531, 2006.

D.R. Albrecht, G.H. Underhill, T.B. Wassermann, R.L. Sah, and S.N. Bhatia, “Probing the role of multicellular organization in 3D microenvironments,” Nature Methods, vol. 3, pp. 369-375, Apr. 2006.

T.J. Harris, G. von Maltazhn, A.M. Derfus, E. Rouslahti, and S.N. Bhatia, “Proteolytic actuation of nanoparticle self-assembly,” Agnewandte Chemie International Edition, vol. 41, no. 19, pp. 3161-3165, 2006.

J.H. Park, A.M. Derfus, E. Segal, K.S. Vecchio, S.N. Bhatia, and M.J. Sailor, “Local heating of discrete droplets using magnetic porous silicon-based photonic crystals,” Journal of the American Chemical Society, vol. 128, no. 24, pp. 7938-7946, 2006.

C. Flaim, S. Chien, and S.N. Bhatia, “An extracellular matrix microarray for probing cellular differentiation,” Nature Methods, vol. 2, no. 2, pp. 119-125, 2005.

J.W. Allen, S.R. Khetani and S.N. Bhatia, “In vitro zonation and toxicity in a hepatocyte bioreactor,” Toxicological Sciences, vol. 84, pp. 110-119, Mar. 2005.

V. Chin, S. Sanga, P. Taupin, J. Scheel, F.G. Gage, and S.N. Bhatia, “A microfabricated platform for studying stem cell fates,” Biotechnology and Bioengineering, vol. 88, no. 3, pp. 399-415, Mar. 2004.

D. Albrecht, R. Sah and S.N. Bhatia, “Geometric and material determinants of patterning efficiency by dielectrophoresis,” Biophysical Journal, vol. 87, no. 4, pp. 2131-2147, Apr. 2004.