MTL Annual Report

Collaborators

• S. Tannenbaum, BE, MIT
• S. Manalis, BE, MIT
• M. Rubner, DMSE, MIT
• R. Cohen, ChemE, MIT
• N. Hadjiconstantinou, ME, MIT
• N.-T. Nguyen, NTU, Singapore
• C. T. Lim, NUS, Singapore
• K. Van Vliet, MSE, MIT
• S. Suresh, MSE, MIT

Graduate Students

• H. Bow, Research Assistant, EECS
• Leon Li, Research Assistant, EECS / HST
• Lih Feng Cheow, Research Assistant, EECS
• Aniruddh Sarkar, Research Assistant, EECS
• Sha Huang, Research Assistant, EECS
• Rho-Kyun Kwak, Research Assistant, ME
• Han Wei Hou, Research Assistant, NUS Bioengineering (SMART)
• Wong Cheng Lee, Research Assitant, NUS Bioengineerig (SMART)

Research Staff

• Y. Song, Ph.D.
• S. Kim, Ph.D.
• H. Y. Gan, Ph. D.
• Z. Li, Ph. D.
• C. H. Chen, Ph. D.
• Ali Bhagat, Ph. D. (SMART)
• Weng Kung Peng, Ph.D. (SMART)

Support Staff

• S. Davco, Administrative Assistant

Publications

Sung Jae Kim, Leon Li, and Jongyoon Han, “Amplified Electrokinetic Response by Concentration Polarization near Nanofluidic Channel,” Langmuir, 25, 7759-7765, 2009.

Lee, J.H., B. Cosgrove, A.D. Lauffenburger, and J. Han, “Microfluidic concentration-enhanced cellular kinase activity assay.” Journal of the American Chemical Society, 131, 10340-10341, 2009.

Yamada, M., P. Mao, J. Fu, and J. Han, “Rapid quantification of disease-marker proteins using continuous-flow immunoseparation in a nano-sieve fluidic device.” Analytical Chemistry, 81, 7067-7074, 2009

Zi Rui Li, G. R. Liu, J. Han, Y. Cheng, Y. Z. Chen, J.-S. Wang, N. G. Hadjiconstantinou, “Analytical description of Ogston-regime biomolecule separation using nanofilters and nanopores” Physical Review E, 80, 041911, 2009.

Fu, J., P. Mao, and J. Han, “Continuous-Flow Bioseparation Using Microfabricated Anisotropic Nanofluidic Sieving Structures,” Nature Protocols, 4, 1681-1698, 2009.

Kim, S.J., Song, Y.-A. & Han, J. “Nanofluidic Concentration Device for Biomolecules Utilizing Ion Concentration Polarization: Theory, Fabrication, and Applications,” Chemical Society Reviews, 39, 912-922, 2010.

Kim, Pilnam, Kim, Sung Jae, and Han, Jongyoon, Suh, Kahp Y. “Stabilization of Ion Concentration Polarization Using a Heterogeneous Nanoporous Junction,” Nano Letters, 10, 16-23, 2010.

Song, Y.-A.; Chan, M.; Celio, C.; Tannenbaum, S. R.; Wishnok, J. S.; Han, J., “Free-Flow Zone Electrophoresis of Peptides and Proteins in PDMS Microchip for Narrow pI Range Sample Prefractionation Coupled with Mass Spectrometry,” Analytical Chemistry, 82, 2317-2325, 2010.

DeRocher, J. P.; Mao, P.; Han, J.; Rubner, M. F.; Cohen, R. E., “Layer-by-Layer Assembly of Polyelectrolytes in Nanofluidic Devices,” Macromolecules, 43, 2430-2437, 2010.

Sung Jae Kim, Sung Hee Ko, Kwan Hyoung Kang, and Jongyoon Han, “Direct Seawater Desalination by Ion Concentration Polarization,” Nature Nanotechnology, 5, 297-301, 2010.

Vincent Liu, Yong Ak Song, and Jongyoon Han, “Capillary-valve-based fabrication of ion-selective membrane junction for electrokinetic sample preconcentration in PDMS chip,” Lab on a Chip, published on the web (10.1039/b923214a), 2010.

Cheow, L. F.; Ko, S. H.; Kim, S. J.; Kang, K. H.; Han, J., “Increase of Sensitivity and Dynamic Range of ELISA using Multiplexed Electrokinetic Concentrator,” Analytical Chemistry, 82, 3383-3388, 2010.

Jeong Hoon Lee and Jongyoon Han, “Concentration-enhanced rapid detection of human chorionic gonadotropin (hCG) as a tumor marker using a nanofluidic preconcentrator,” Microfluidics and Nanofluidics, Accepted for publication (DOI: 10.1007/s10404-010-0598-z), 2010.

Ali Asgar. S. Bhagat, Hansen Bow, Han Wei Hou, Swee Jin Tan, Chwee Teck Lim, Jongyoon Han, “Microfluidics for Cell Separation,” accepted for publication, 2010.

Yamada, M.; Mao, P.; Fu, J.; Han, J. “CONTINUOUS-FLOW IMMUNOSEPARATION AND RAPID QUANTIFICATION OF PROTEIN BINDING KINETICS IN ANISOTROPICALLYPATTERNED NANO-SIEVE STRUCTURES,” Proceedings of the MicroTAS 2009 Symposium, Jeju, Korea, pp 1982-1984, November 2009.

Lee, J. H.; Cosgrove, B. D.; Lauffenburger, D. A.; Han, J. “IN-VITRO CONCENTRATION-ENHANCED CELLULAR KINASE ACTIVITY ASSAYS DIRECTLY FROM CELL LYSATES,” Proceedings of the MicroTAS 2009 Symposium, Jeju, Korea, pp 1341-1343, November 2009.

Cheow, L. F.; Ko, S. H.; Kang, K. H.; Han, J., “ELECTROKINETIC ACCUMULATION OF ENZYMATIC PRODUCT ENHANCES DETECTION SENSITIVITY IN MICROFLUIDIC ELISA,” Proceedings of the MicroTAS 2009 Symposium, Jeju, Korea,  pp 939-941, November 2009.

Bow, H.; Hou, H. W.; Goldfless, S.; Abgrall, P.; Tan, K.; Niles, J.; Lim, C. T.; Han, J., “CONTINUOUS-FLOW DEFORMABILITY-BASED SORTING OF MALARIA-INFECTED RED BLOOD CELLS,” Proceedings of the MicroTAS 2009 Symposium, Jeju, Korea, pp 1219-1221, November 2009

Ko, S. H.; Kim, S. J.; Kang, K. H.; Han, J. “LIMITING CONVECTION NEAR ION SELECTIVE NANOJUNCTION LEADS TO THE REMOVAL OF LIMITING CURRENT BEHAVIOR,” Proceedings of the MicroTAS 2009 Symposium, Jeju, Korea, pp 168-170, November 2009.

Kim, P.; Kim, S. J.; Han, J.; Suh, K. Y. “Microfluidic Integration of Cation- and Anion-Selective Hydrogels for Molecular Manipulation,” Proceedings of the MicroTAS 2009 Symposium, Jeju, Korea, pp 848-850, November 2009.

Kim, S. J.; Ko, S. H.; Kang, K. H.; Han, J., “DIRECT SEAWATER DESALINATION USING IONIC CONCENTRATION POLARIZATION,” Proceedings of the MicroTAS 2009 Symposium, Jeju, Korea, pp 1276-1278, November 2009.