All entries for eric winokur

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A Wearable, Long-term Cardiac Monitor

• Authors: M. K. Delano, E. S. Winokur, C. G. Sodini
• Sponsorship: Texas Instruments

With the escalating costs of hospital visits, clinicians are opting to use at-home monitoring devices to diagnose patients.  Current ECG Holter monitoring devices typically have 24-48 hour memory and battery capacity ^[1] .  With many patients experiencing intermittent heart problems that can occur once every week or month, an event recorder or loop recorder is required ^[2] .  However, event recorders can save only up to a few minutes of ECG recordings.  This constraint leads to the loss of most of the data, which could be very important in alerting the user to the onset of future episodes.  Therefore, we have developed a Holter monitor prototype with the goal of battery and memory capacity of greater than one week.  Figure 1 shows a block diagram of the system.

We based the long-term monitor prototype around a Texas Instruments MSP430 low-power microcontroller that enables high computing power with very low power consumption.  The prototype monitor is mounted on standard 3M 2560 Red Dot electrodes. The central board is fabricated on a flexible PCB substrate.  Mounting the PCB directly on the electrodes improves the SNR by an estimated 40 dB compared to using wired leads ^[3] .  The monitor is “L”-shaped with rounded corners and placed on the patient’s chest (Figure 2).  The “L” shape enables several different ECG vectors to be recorded, depending on what the cardiologist wants to observe.  The monitor has a micro SD card on board, which is enough to store weeks of ECG data sampled at 250 Hz continuously, without compression.



Figure 1: Block diagram of the ECG long-term Holter monitor system. The front end uses TI OPA333 and INA333 amplifiers and has a bandwidth from 0.5 Hz to 125 Hz. The 3-axis ADI accelerometer samples data at 12.5Hz to help correlate activity level with the ECG recordings. The battery is a 3.7V 600 mAh Li-Pol cell from Cameron-Sino.



Figure 2: A photo of the wearable, long-term cardiac monitor. The monitor is coated in Parylene C to protect it from water and sweat that may come in contact with the circuits.




1. D. Jabaudon, J. Sztajzel, K. Sievert, T. Landis, and R. Sztajzel, “Usefulness of ambulatory 7-day ECG monitoring for the detection of atrial fibrillation and flutter after acute stroke and transient ischemic attack,” Stroke, J. Amer. Heart Assoc., vol. 35, pp. 1647–1651, May 2004. [↩]
2. M. A. Rockx, J. S. Hoch, G. J. Klein, R. Yee, A. C. Skanes, L. J. Gula, and A. D. Krahn, “Is ambulatory monitoring for “Community-acquired” syncope economically attractive? A cost-effective analysis of a randomized trial of external loop recorders versus Holter monitoring,” AHJ vol. 150, no. 5, pp. 1065.e1-1065.e5, Nov. 2005. [↩]
3. A. Searle and L. Kirkup, “A direct comparison of wet, dry and insulating bioelectric recording electrodes,” Physiol. Meas., vol. 21, pp. 271-283, 2000. [↩]

A Wearable Vital-signs Monitor at the Ear

• Authors: E. Winokur, D. He, C. Sodini
• Sponsorship: MEDRC, NSERC Fellowship

Vital signs such as heart rate, blood pressure, blood oxygenation, cardiac output, and respiratory rate are necessary in determining the overall health of a patient.  Continuous monitoring of these vital signs can help healthcare workers assess the wearer’s overall state of health and identify risks for cardiovascular diseases ^[1] .

We propose the site behind the ear as a location for an integrated wearable vital signs monitor ^[2] . This location offers physiological signals such as the electrocardiogram (ECG), the photoplethysmogram (PPG), and the ballistocardiogram (BCG). The ECG measures the electrical activity from the heart and offers heart rate information. The PPG measures the blood volume and color under the skin using optical illumination. The PPG offers information such as continuous heart rate and blood oxygenation. The BCG measures the body’s mechanical reaction to the blood expelled by the heart and also provides the heart rate.

Using the peak timing data from ECG and BCG, the heart’s pre-ejection period (PEP) can be measured ^[3] . The PEP is a measure of heart contractility and heart muscle health. Figure 1 compares the measured RJ interval and PEP during a Valsalva breath-holding maneuver.

The device is designed to use the ear as a discreet and a natural anchor that reduces device visibility and the need for skin adhesives. A photo of our prototype device is shown in Figure 2. While the prototype currently uses off-the-shelf components, custom integrated circuits are being designed to replace those components to significantly decrease the device’s size and power consumption.



Figure 1: Top – The RJ interval timing from the ECG and BCG during a Valsalva maneuver. Bottom – Simultaneously measured pre-ejection period (PEP).



Figure 2: Left – The wearable vital signs monitor. Center – A PC USB wireless receiver. Right – The vital signs monitor being worn at the ear with ECG electrodes attached.




1. S. D. Pierdomenico, M. Di Nicola, A. L. Esposito, R. Di Mascio, E. Ballone, D. Lapenna and F. Cuccurullo, “Prognostic value of different indices of blood pressure variability in hypertensive patients,” American Journal of Hypertension, pp. 842-847, June 2009. [↩]
2. D. He, E. S. Winokur, T. Heldt, and C. G. Sodini, “The ear as a location for wearable vital signs monitoring,” IEEE Engineering in Medicine and Biology Conference, pp. 6389-6392, Sept. 2010. [↩]
3. D. He, E. S. Winokur, and C. G. Sodini, “A continuous, wearable, and wireless heart monitor using head ballistocardiogram (BCG) and head electrocardiogram (ECG),” IEEE Engineering in Medicine and Biology Conference, pp. 4729-4732, Aug. 2011. [↩]