MTL Annual Research Report 2011

Collaborators

• C. Chen (BME), UPenn
• S. Duncan, M.C. Wisconsin
• B. Engelward (BE), MIT
• T. Golub, (Broad Institute), MIT
• D. Haber/M. Toner (MGH)
• W.  Hahn, (Broad Institute), MIT
• S. Hoffman (Sanaria)
• R. Langer/D. Anderson, MIT
• D. Livingston (DFCI)
• L. Mahadevan (SEAS), Harvard
• D. Melton (SCRB), Harvard
• C. Rice, Rockefeller
• E. Ruoslahti (Burnham Institute)
• M. Sailor (Chemistry), UCSD
• D. Schuppan (BIDMC)
• P. Sharp (Biology), MIT
• J. Shah (Systems Bio), Harvard
• P. Zandstra, U Toronto

Postdoctoral Associates

• G. Kwong
• D. Wood
• N. Singh
• K. Stevens
• R. Schwartz
• K. Christine
• S. Hauert
• S. Desai

Graduate Students

• S. Ng, Research Assistant, BE
• J. Lo, Research Assistant, HST
• A. Bagley, Research Assistant, HST
• Y. Ren, Research Assistant, HST
• J. Shan, Research Assistant, HST
• N. Reticker-Flynn, Res. Asst., HST
• D. Malta, Research Assistant, HST
• K. Trehan, Research Assistant, HST
• K. Lin, Research Assistant, ChE
• C. Li, Research Assistant, ChE

Support Staff

• S. Kangiser, Admin. Assistant
• S. Katz, Laboratory Manager
• E. Lehtola, Research Technician
• L. Ingaharro, Research Technician
• G. Underhill, Research Scientist
• S. March-Riera, Research Scientist

Publications

von Maltzahn, G, Park, JH, Lin, KY, Singh, N, Schwöppe, C, Mesters, R, Berdal, WE, Ruoslahti, E, Sailor, MJ, and Bhatia, SN (2011): Nanoparticles that communicate in vivo to amplify tumour targeting. Nature Materials. Advanced online publication, doi:10.1038/nmat3049.

Chen, AA, Underhill, GH, and Bhatia, SN (2010): Multiplexed, high-throughput analysis of 3D microtissue suspensions. Integrative Biology, 2: 517-527.

Wood, DK, Weingeist, DM, Bhatia, SN, and Engelward, BP (2010): Single cell trapping and DNA damage analysis using microwell arrays. PNAS, 107: 10008-10013

Ploss, A, Khetani, SR, Jones, CT, Sydera, AJ, Trehan, K, Gaysinskaya, VA, Mua, K, Ritola, K, Rice, CM, and Bhatia, SN (2010): Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures. PNAS. 107: 3141-3145.

Agrawal, A, Min, D-H, Singh, N, Zhu, H, Birjiniuk, A,von Maltzahn, G, Harris, T, Xing, D, Woolfenden, S, Sharp, P, Charest, A, and Bhatia, SN (2009): Functional delivery of siRNA in mice using dendriworms. ACS Nano. 3: 2495–2504.

March, S, Hui, EE, Underhill, GH, Khetani, S, and Bhatia, SN (2009). Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro. Hepatology, 50: 920-928.

von Maltzahn, G., Park, J-H, Agrawal, A, Bandaru, NK, Das, SK, Sailor, MJ, and Bhatia, SN (2009):  Computationally-guided photothermal tumor therapy using long-circulating gold nanorod antennas. Cancer Research. 69: 3892-3900.

Khetani, SR, and Bhatia, SN (2008): Microscale human liver tissue for drug development. Nature Biotechnology, 26 (1): 120-126.

Hui, EE and Bhatia, SN (2007). Micromechanical control of cell-cell interactions. PNAS, 104: 5722-5726.

Liu Tsang, V, Chen, AA, Cho, LM, Jadin, KD, Sah, RL, DeLong, S, West, JL, and Bhatia, SN (2007) Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels. FASEB Journal, 21: 790-801.