MTL Annual Research Report 2011

Collaborators

• J. P. Theiey, A*STAR Institute for Molecular and Celllar Biology
• M. Raghunath, National University of Singapore
• R. Lee, Brigham and Women’s Hospital
• M. Lang, Vanderbilt University
• P. So, MechE/BE
• H. Asada, MIT, MechE
• D. Lauffenburger, MIT, BE
• L. Griffith, MIT, BE

Graduate Students

• J. Jeon, Res. Asst., MechE
• I. Zervantonakis, Research Assist., ME
• V. Vickerman, Res. Asst., ChemE
• W. Polacheck, Res. Asst., MechE
• J. Whisler, Res. Asst., MechE
• R. Li, Res. Asst., BE

Support Staff

• S. Megerdichian, Admin. Asst. II

Publications

Vera RH, Genové E, Alvarez L, Borrós S, Kamm R, Lauffenburger D, Semino CE. Interstitial Fluid Flow Intensity Modulates Endothelial Sprouting in Restricted Src-Activated Cell Clusters During Capillary Morphogenesis. Tissue Eng Part A. 2008 Jul 17.

Chung S, Lee JH, Moon M-W, Han J, Kamm RD. Non-lithographic wrinkle nanochannels for protein preconcentration. Adv Mater. 2008, 20:3011-3016.

Das SK, Chung S, Zervantonakis I, Atnafu J, Kamm RD. A microfluidic platform for studying the effects of small temperature gradients in incubator environment. Biomicrofluidics, 2008, 2, 03106.

Chung S, Sudo S, Mack PJ, Wan C-R, Vickerman V, Kamm RD. Cell migration into scaffold under co-culture conditions in a microfluidic platform. Lab Chip, 2009, 9(2):269-75.

Mack PJ, Zhang Y, Chung S, Vickerman V, Kamm RD, Garcia-Cardena G. Biomechanical regulation of endothelium-dependent events critical for adaptive remodeling. J Biol Chem. 2009, 284(13):8412-8420.

Sudo R, Chung S, Zervantonakis IK, Vickerman V, Toshimitsu Y, Griffith LG, Kamm RD. Transport-mediated angiogenesis in 3D epithelial coculture. FASEB J, 2009, 23(7):2155-64.

Chung S, Yun H and Kamm RD. Nanointerstice-driven microflow. Small, 2009, 5(5) 609-13.DOI: 10.1002/smll.200800748.

Chung S, Sudo R, Zervantonakis I, Rimchala T, Kamm RD. Surface-treatment-induced three-dimensional capillary morphogenesis in a microfluidic platform. (Cover Article) Adv Mat, 21: 1-5, 2009. DOI: 10.1002/adma.2009001727

Wood LB, Das A, Kamm RD, Asada HH. A stochastic broadcast feedback approach to regulating cell population morphology for microfluidic angiogenesis platforms. IEEE Trans Biomed Eng. 2009 Sep;56(9):2299-303. Epub 2009 Jul 17.

Mofrad MR, Kamm RD, eds.  Cellular Mechanotransduction: Diverse Perspectives from Molecules to Tissues, Cambridge University Press, 2009.

Chung S, Sudo S, Vickerman V, Zervantonakis IK, Kamm RD. Microfluidic Platforms for Studies of Angiogenesis, Cell Migration, and Cell–Cell Interactions, Annals Biomed Engineering, 2010, DOI: 10.1007/s10439-010-9899-3

Zervantonakis IK, Chung S, Sudo R, Zhang M, Charest JL, Kamm RD. Concentration gradients in microfluidic 3D matrix cell culture systems. Intern J Micro-Nano Scale Transport, 1(1): 27-36, 2010.

Lee H, Ferrer JM, Nakamura F, Lang MJ, Kamm RD. Passive and active microrheology for cross-linked F-actin networks in vitro.  Acta Biomater. 2010 Apr;6(4):1207-1218. Epub 2009 Oct 31

Amadi OC, Steinhauser ML, Nishi Y, Chung S, Kamm RD, McMahon AP, Lee RT. A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment. Biomed Microdevices. 2010 Dec;12(6):1027-41. PubMed PMID: 20661647.

Kothapalli CR, van Veen E, de Valence S, Chung S, Zervantonakis IK, Gertler FB, Kamm RD. A high-throughput microfluidic assay to study neurite response to growth factor gradients. Lab Chip. 2011 Feb 7;11(3):497-507. Epub 2010 Nov 25. PubMed PMID: 21107471.

Wan CR, Chung S, Kamm RD. Differentiation of Embryonic Stem Cells into Cardiomyocytes in a Compliant Microfluidic System. Ann Biomed Eng. 2011 Feb 19. [Epub ahead of print] PubMed PMID: 21336802.

Honarmandi P, Lee H, Lang MJ, Kamm RD. A microfluidic system with optical laser tweezers to study mechanotransduction and focal adhesion recruitment. Lab Chip. 2011 Feb 21;11(4):684-94. Epub 2010 Dec 8. PubMed PMID: 21152510.

Jeon JS, Chung S, Kamm RD, Charest JL. Hot embossing for fabrication of a microfluidic 3D cell culture platform. Biomed Microdevices. 2011 Apr;13(2):325-33. PubMed PMID: 21113663.