MTL Annual Research Report 2011

Graduate Students

• H. Hsi, Res. Asst., ChemE
• X. Yang, Res. Asst., ChemE
• A. Tatusko, Res. Asst., ChemE
• L. Tan, Res. Asst., ChemE

Postdoctoral Associate

• J. Chen, ChemE
• B.C. Sarma, ChemE
• S.Y. Wong, ChemE
• M. Su, ChemE
• I. Miroshnyk, ChemE

UROP

• A.S. Fried, ChemE
• A. Simi, ChemE

Support Staff

• G. Collver-Jacobson
• P. Romanow

Publications

Diao, Y., Myerson, A.S., Hatton, T.A., and Trout, B. L.  (2011).  Surface Design for Controlled Crystallization:  The Role of Surface Chemistry and Nanoscale Pores in Heterogeneous Nucleation. Langmuir (accepted).

Diao, Y., Hegelson, M.E., Myerson, A. S., Hatton, T. A.,  Doyle, P. S., and Trout, B.L.  (2011).  Controlled Nucleation from Solution Using Polymer Microgels.  Journal of the American Chemical Society 133, 3756-3759.

Lee, A.Y., Erdemir, D, Myerson, A.S. (2011).  Crystal Polymorphism in Chemical Process Development.  The Annual Review of Chemical and Biomolecular Engineering(published on web).

Chen J., Sarma B., Evans J. M.B., and Myerson A.S. (2011) Pharmaceutical Crystallization. Crystal Growth and Design, published on web.

Sarma B., Chen J., Hsi H.Y., and Myerson A.S. (2011) Solid forms of pharmaceuticals: Polymorphs, salts and cocrystals. Korean Journal of Chemical Engineering, 28, 315-322.

Kim, K, Centrone, A., Hatton, T.A., and Myerson, A.S. (2011) Polymorphism control of nanosized glycine crystals on engineered surfaces. Cryst. Eng. Comm. 13, 1127-1131.

Singh, A, Lee, I.S., Kim, K. and Myerson, A.S. (2011).  Crystal Growth on Self-assembled Monolayers.  Cryst. Eng. Comm. 13, 24-31.

Singh, A. and Myerson, A.S. (2010). Chiral Self Assembled Monolayers as Resolving Auxiliaries in the Crystallization of  Valine. Journal of Pharmaceutical Science 99, 3931-3940.

Alvarez, A. and Myerson, A.S. (2010).  Plug Flow Crystallization of Pharmaceutical Compounds.  Crystal Growth and Design 10, 2219-2228.

Kim, K, Lee, I.S., Centrone, A., Hatton, T.A. and Myerson, A.S. (2009). Formation of Nanosized Organic Molecular Crystals on Engineered Surfaces. Journal of the American Chemical Society 131, 18212-18213.

Alvarez, A., Sing, A., and Myerson, A.S. (2009). Polymorph Screening: Comparing a Semi-Automated Approach with a High Throughput Method. Crystal Growth and Design 9, 4181-4188.

Aldabaibeh, N., Jones, M., Myerson, A.S., Ulrich, J. (2009). The Solubility of Orthorhombic Lysozyme Crystals Grown at Low pH. Crystal Growth and Design 9, 3313-3317.

Erdemir, D, Lee, A.Y., and Myerson, A.S. (2009). Nucleation of Crystals From Solution: Classical and Two Step Models. Accounts of Chemical Research 42, 621-629.

Singh, A., Lee, I.S., and Myerson, A.S. (2009). Concomitant Crystallization of ROY on Patterned Substrates: Using a High Throughput Method to Improve the Chances of Crystallization of Different Polymorphs. Crystal Growth and Design 9, 1182-1185.

Konkel, J.T., and Myerson, A.S. (2008). Empirical Molecular Modeling of a Suspension Stabilization Using Polysorbate 80. Molecular Simulation 34, 1353-1357.

Lee, I.S., Evans, J.M.B., Erdemir, D., Lee, A.Y., Garetz, B.A and Myerson, A.S., (2008). Non Photochemical Laser Induced Nucleation of Hen White Lysozyme Crystals.Crystal Growth and Design 8, 4455-4461.

Sun, X., Garetz, B.A., and Myerson, A.S., (2008). Polarization Switching of Crystal Structure in the Non-Photochemical Laser Induced Nucleation of Supersaturated Aqueous L-Histidine. Crystal Growth and Design 8, 1720-1722.

Lee, I.S., Kim, K.T., Lee, A.Y. and Myerson, A.S., (2008). Concomitant Crystallization of Glycine on Patterned Substrates: The Effect of pH on the Polymorphic Outcome.Crystal Growth and Design, 8, 108-113.

Lee, I.S., Lee, A.Y., and Myerson, A.S.,  (2008).  Concomitant Polymorphism in Confined Environment:  Implication to Crystal Form Screening.  Pharmaceutical Research, 25, 960-968.