{"id":5636,"date":"2012-07-18T22:28:04","date_gmt":"2012-07-18T22:28:04","guid":{"rendered":"https:\/\/mtlsites.mit.edu\/annual_reports\/2012\/?p=5636"},"modified":"2012-07-18T22:28:04","modified_gmt":"2012-07-18T22:28:04","slug":"microfluidic-device-for-characterization-of-dynamic-red-blood-cell-deformability","status":"publish","type":"post","link":"https:\/\/mtlsites.mit.edu\/annual_reports\/2012\/microfluidic-device-for-characterization-of-dynamic-red-blood-cell-deformability\/","title":{"rendered":"Microfluidic Device for Characterization of Dynamic Red Blood Cell Deformability"},"content":{"rendered":"<p>The average diameter of human red blood cells (RBCs) is around 8\u00b5m. As RBCs circulate in the body and transport oxygen, they have to deform repeatedly in small blood capillaries. RBC deformability is therefore an important mechanical attribute for efficient oxygen delivery. Several blood related diseases such as malaria, sickle cell anemia, and sepsis are marked with significant alterations in RBC deformability<sup> [<a href=\"#footnote_0_5636\" id=\"identifier_0_5636\" class=\"footnote-link footnote-identifier-link\" title=\"A. M. Dondorp, E. Pongponratn, and N. J. White, &ldquo;Reduced microcirculatory flow in severe falciparum malaria: Pathophysiology and electron-microscopic pathology, Acta Tropica vol. 89, pp. 309-317, 2004.\">1<\/a>] <\/sup><sup> [<a href=\"#footnote_1_5636\" id=\"identifier_1_5636\" class=\"footnote-link footnote-identifier-link\" title=\"O. K. Baskurt, D. Gelmont,&nbsp; and H. J. Meiselman, &ldquo;Red blood cell deformability in sepsis,&rdquo; American Journal of Respiratory and Critical Care Medicine, &nbsp;vol. 157, pp. 421-427, 1998.\">2<\/a>] <\/sup><sup> [<a href=\"#footnote_2_5636\" id=\"identifier_2_5636\" class=\"footnote-link footnote-identifier-link\" title=\"S. Chien, &ldquo;Red cell deformability and its relevance to blood flow,&rdquo; Ann. Rev. Physiol. vol. 49, pp. 177-192, 1987.\">3<\/a>] <\/sup>.<\/p>\n<p>This project studies RBC dynamic deformability using a simple, portable microfluidic device<sup> [<a href=\"#footnote_3_5636\" id=\"identifier_3_5636\" class=\"footnote-link footnote-identifier-link\" title=\"H. Bow, IV. Pivkin, M. Diez-Silva, S.J. Goldfless, M. Dao, J.C. Niles, S. Suresh, and J. Han, A microfabricated deformability-based flow cytometer with application to malaria, Lab on a Chip, vol. 11, pp. 1065-1073, 2011.\">4<\/a>] <\/sup>. The deformability of individual RBCs can be assessed by the average velocity of RBCs passing through narrow microfluidic channels. The repeated deformations to be experienced by RBCs simulate <em>in vivo<\/em> blood capillary system. Several blood-related diseases are included in our studies.<\/p>\n<ol class=\"footnotes\"><li id=\"footnote_0_5636\" class=\"footnote\">A. M. Dondorp, E. Pongponratn, and N. J. White, &#8220;Reduced microcirculatory flow in severe falciparum malaria: Pathophysiology and electron-microscopic pathology, <em>Acta Tropica<\/em> vol. 89, pp. 309-317, 2004. [<a href=\"#identifier_0_5636\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>] <\/li><li id=\"footnote_1_5636\" class=\"footnote\">O. K. Baskurt, D. Gelmont,\u00a0 and H. J. Meiselman, &#8220;Red blood cell deformability in sepsis,&#8221; <em>American Journal of Respiratory and Critical Care Medicine, <\/em>\u00a0vol. 157, pp. 421-427, 1998. [<a href=\"#identifier_1_5636\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>] <\/li><li id=\"footnote_2_5636\" class=\"footnote\">S. Chien, &#8220;Red cell deformability and its relevance to blood flow,&#8221; <em>Ann. Rev. Physiol.<\/em> vol. 49, pp. 177-192, 1987. [<a href=\"#identifier_2_5636\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>] <\/li><li id=\"footnote_3_5636\" class=\"footnote\">H. Bow, IV. Pivkin, M. Diez-Silva, S.J. Goldfless, M. Dao, J.C. Niles, S. Suresh, and J. Han, A microfabricated deformability-based flow cytometer with application to malaria, <em>Lab on a Chip, <\/em>vol<em>.<\/em> 11, pp. 1065-1073, 2011. [<a href=\"#identifier_3_5636\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>] <\/li><\/ol>","protected":false},"excerpt":{"rendered":"<p>The average diameter of human red blood cells (RBCs) is around 8\u00b5m. As RBCs circulate in the body and transport&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[29],"tags":[51,6202],"_links":{"self":[{"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2012\/wp-json\/wp\/v2\/posts\/5636"}],"collection":[{"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2012\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2012\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2012\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2012\/wp-json\/wp\/v2\/comments?post=5636"}],"version-history":[{"count":3,"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2012\/wp-json\/wp\/v2\/posts\/5636\/revisions"}],"predecessor-version":[{"id":6404,"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2012\/wp-json\/wp\/v2\/posts\/5636\/revisions\/6404"}],"wp:attachment":[{"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2012\/wp-json\/wp\/v2\/media?parent=5636"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2012\/wp-json\/wp\/v2\/categories?post=5636"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2012\/wp-json\/wp\/v2\/tags?post=5636"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}