{"id":3821,"date":"2011-07-13T15:14:01","date_gmt":"2011-07-13T15:14:01","guid":{"rendered":"https:\/\/mtlsites.mit.edu\/annual_reports\/2011\/?p=3821"},"modified":"2011-07-19T14:51:29","modified_gmt":"2011-07-19T14:51:29","slug":"bevin-engelward","status":"publish","type":"post","link":"https:\/\/mtlsites.mit.edu\/annual_reports\/2011\/bevin-engelward\/","title":{"rendered":"Bevin Engelward"},"content":{"rendered":"<div class=\"pf-content\"><h3>Collaborators<\/h3>\n<ul>\n<li>R. Sobol, University of Pittsburgh Cancer Institute<\/li>\n<li>S. Bhatia, Harvard-MIT Division of Health Science and Technology<\/li>\n<li>P. Hammond, ChemE<\/li>\n<\/ul>\n<h3>Senior Postdoctoral Associate<\/h3>\n<ul>\n<li>O. Kiraly<\/li>\n<\/ul>\n<h3>Graduate Students<\/h3>\n<ul>\n<li>J. Ge, Research Assistant, BE<\/li>\n<li>M. Parrish, Research Assistant, BE<\/li>\n<li>M. Sukup Jackson, Research Assistant, BE<\/li>\n<li>D. Weingeist, Research Assistant, BE<\/li>\n<\/ul>\n<h3>Support Staff<\/h3>\n<ul>\n<li>K. Reposa, Administrative Assistant II<\/li>\n<li>P. Mazzucato, Lab Technician<\/li>\n<\/ul>\n<h3>Publications<\/h3>\n<p>Engelward, B.P., Dreslin, A., Christensen, J., Huszar, D., Kurahara, C., and Samson, L.,\u00a0 Repair deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation induced chromosome damage and cell killing, <em>EMBO J<\/em>., 15: 945-952 (1996).\u00a0 PMCID: PMC450292<\/p>\n<p>Engelward, B.P., Weeda, G., Wyatt, M.D., Broekhof, J.L.M., de Wit, J., Donker, I., Allan, J.M., Gold, B.,Hoeijmakers, J.H.J., and Samson, L.D., Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase, <em>Proc. Natl. Acad. Sci. USA, <\/em>94: 13087-13092 (1997)<em>.<\/em> PMCID: PMC24267<em> <\/em><\/p>\n<p>Engelward, B.P., Allan, J.M., Dreslin, A.J., Kelly, J.D., Wu, M.M., Gold, B., and Samson, L.D., A chemical and genetic approach together define the biological consequences of 3-methyladenine lesions in the mammalian genome, <em>J. Biol. Chem.,<\/em> 273: 5412-5418 (1998).\u00a0 PMID: 9479003<\/p>\n<p>Hendricks, C.A., Razlog, M., Matsuguchi, T., Goyal, A., Brock, A.L., and Engelward, B.P., The<em> S. cerevisiae <\/em>Mag1 3-methyladenine DNA glycosylase modulates susceptibility to homologous recombination, <em>DNA Repair, <\/em>1: 645-659 (2002).\u00a0 PMID: 12509287<\/p>\n<p><em> <\/em><\/p>\n<p>Hendricks, C.A.,\u00a0 Almeida, K., Stitt, M.,\u00a0 Jonnalagadda, V.,\u00a0 Kerrison, F., Rugo, R.,Engelward,B.P.,Spontaneous mitotic homologous recombination at an EYFP direct repeat in transgenic mice, <em>Proc. Natl. Acad. Sci. USA,<\/em> 100: 6325-6330(2003).\u00a0 PMCID: PMC164445<\/p>\n<p>Kiziltepe, T., Yan, A., Dong, M., Jonnalagadda, V.S., Dedon, P.C., and Engelward, B.P., Delineation of the chemical pathways underlying nitric oxide-induced homologous recombination in mammalian cells, <em>Chem. Biol., <\/em>3: 357-369 (2005).\u00a0 PMID: 15797220<\/p>\n<p>Jonnalagadda, V.S., Matsuguchi, T., and Engelward, B.P., Interstrand crosslink-induced homologous recombination carries an increased risk of deletions and insertions<em>, DNA Repair<\/em>, 4: 594-605 (2005).\u00a0 PMID: 15811631<\/p>\n<p>Rugo, R.E., Almeida, K.H., Hendricks, C.A., Jonnalagadda, V.S., and Engelward, B.P., A single acute exposure to a chemotherapeutic agent induces hyper-recombination in distantly descendant cells and in their neighbors, <em>Oncogene<\/em>, 25:5016-5025 (2005)<em>.<\/em> PMID: 15856014<\/p>\n<p>Wiktor-Brown, D.M., Hendricks, C.A., Olipitz, W., and Engelward, B.P., Age dependent accumulation of recombinant cells in the mouse pancreas revealed by <em>in situ<\/em> fluorescence imaging, <em>Proc. Natl. Acad. Sci. U.S.A.<\/em>, 103:11862-11867 (2006).\u00a0 PMCID: PMC1567667<\/p>\n<p>Wiktor-Brown, D.M., Olipitz W., Hendricks C.A., Rugo R.E., and Engelward B.P., Tissue specific differences in the accumulation of sequence rearrangements with age, <em>DNA Repair<\/em>, 7:694-703 (2008).\u00a0 PMCID: PMC3014828<\/p>\n<p>Wiktor-Brown, D.M., Kwon H.S., Nam Y.S., So P.T., and Engelward B.P., Integrated one- and two-photon imaging platform reveals clonal expansion as a major driver of mutation load, Proc<em>. Natl. Acad. Sci. U. S. A<\/em>., 105:10314-10319 (2008).\u00a0 PMCID: PMC2492490<\/p>\n<p>Niu, Y., Wang H., Wiktor-Brown D.M., Rugo R., Shen H., Huq S., Engelward B.P., Epperly M., and Greenberger J.S., Irradiated esophageal cells are protected from radiation-induced recombination by MnSOD gene therapy, <em>Rad. Res<\/em>., 173:453-61 (2010). \u00a0PMCID:PMC2872095<\/p>\n<p>Olipitz, W., Hembrador S., Davidson M., Yanch J.C. and Engelward B.P., Development and characterization of a novel variable low-dose rate irradiator for in vivo mouse studies, <em>Health Phys. J.<\/em>, 98:727-34 (2010). \u00a0PMCID:PMC3020895<\/p>\n<p>Wood, D.K., Weingeist D.M., Wu Y., Bhatia S.N., and Engelward B.P. Single cell trapping and DNA damage analysis using microwell arrays, <em>Proc. Natl. Acad. Sci. U.S.A.<\/em>,107:10008-13 (2010).\u00a0 PMCID:PMC2890454<\/p>\n<p>Rugo, R.E., Mutamba J.T., Mohan K.N., Yee T., Chaillet J.R., Greenberger J.S., and Engelward B.P.\u00a0 Methyltransferases mediate cell memory of a genotoxic insult, <em>Oncogene<\/em>, 30: 751\u2013756 (2011).\u00a0 PMCID: PMC3044496<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Animal and cellular models for DNA damage and repair. Single cell microarray high-throughput DNA damage repair platform. Applications to disease susceptibility.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[80],"tags":[6190],"_links":{"self":[{"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2011\/wp-json\/wp\/v2\/posts\/3821"}],"collection":[{"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2011\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2011\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2011\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2011\/wp-json\/wp\/v2\/comments?post=3821"}],"version-history":[{"count":3,"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2011\/wp-json\/wp\/v2\/posts\/3821\/revisions"}],"predecessor-version":[{"id":3945,"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2011\/wp-json\/wp\/v2\/posts\/3821\/revisions\/3945"}],"wp:attachment":[{"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2011\/wp-json\/wp\/v2\/media?parent=3821"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2011\/wp-json\/wp\/v2\/categories?post=3821"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mtlsites.mit.edu\/annual_reports\/2011\/wp-json\/wp\/v2\/tags?post=3821"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}